Sep. 2014 – Jul. 2020, Ph.D. Aerospace Information Research Institute, Chinese Academy of Sciences, Bioelectronics major

Sep. 2010 – Jul. 2014, MS. Department of Measurement and Control Technology and Instrumentation, Beijing University of Chemical Technology, Measurement and control technology and instruments

Jul. 2022 – Present,  Assistant researcher, BNRist, Tsinghua University

Jul. 2020 – Jul. 2022, Postdoc., Department of Automation, Tsinghua University

Mar. 2018 – Mar. 2019, Visiting Scholar, Mechanical Engineering, University of Minnesota

（1）Optical-electrical dual model neural interface devices: design, preparation and application of micro and nano devices

（2）Large-scale neural coding and characterization: neural population coding mechanisms under multi-sensory stimulation.

（3）Neuro-regulation: neuroregulatory strategies and neuro-immune response mechanisms regulated by electrical stimulation.

My research is centered on advanced observation technologies and modeling methods for comprehensive brain function, with a particular emphasis on the development of brain-computer interface devices. I employ photoelectric joint detection and multimodal neural activity recording systems to monitor and analyze large-scale and high-resolution neural activities across different states of consciousness. This includes constructing extensive continuous brain activity monitoring systems in the cerebral cortex and developing multi-nuclear, multimodal detection techniques for deeper brain structures. I leverage photoelectric fusion detection and large-scale data analysis to investigate the neural dynamics and regulatory mechanisms underpinning the transitions between consciousness levels, such as during sleep and anesthesia. Furthermore, my work integrates photogenetic and electrical stimulation strategies to explore the subconscious changes and control patterns in these states. I also study neural representations and computational models under cognitive decision-making paradigms, focusing on the brain’s processing of visual and auditory information.

Published Papers:

[1] Guihua Xiao#; Yeyi Cai#; Yuanlong Zhang; Jingyu Xie; Lifan Wu; Hao Xie; Jiamin Wu*, Qionghai Dai*, Mesoscale neuronal granular trial variability in vivo illustrated by nonlinear recurrent network in silico, Nature Communication, 15, 2024.

[2] Hao Xie#; Xiaofei Han#; Guihua Xiao#; Hanyun Xu; Yuanlong Zhang; Guoxun Zhang; Qingwei Li; Jing He; Dan Zhu; Xinguang Yu; Qionghai Dai*; Multifocal fluorescence video-rate imaging of centimetre-wide arbitrarily shaped brain surfaces at micrometric resolution, Nature Biomedical Engineering, 8, 2024, 740-753.

[3] Penghui Fan#; Rujin Zhang#; Guihua Xiao#; Yilin Song; Chaowei Zhuang; Lekang Yuan; Fan Mo; Botao Lu; Zhaojie Xu; Yiding Wang; Jinping Luo; Mixia Wang; Weidong Mi; Jiangbei Cao*; Qionghai Dai*; Xinxia Cai*; Simultaneous recording of neuronal discharge and calcium activity reveals claustrum-cortex neurosynchrony under anesthesia, Fundamental Research, 2024, 00(00): 00- 00

[4] Yuanlong Zhang, Lekang Yuan, Qiyu Zhu, Jiamin Wu, Tobias Nobauer, Rujin Zhang, Guihua Xiao, Mingrui Wang, Qionghai Dai, Alipasha Vaziri. A miniaturized mesoscope for the large-scale single-neuron-resolved imaging of neuronal activity in freely behaving mice. Nature Biomedical Engineering, 8, 2024, 754–774.

[5] Zhi Lu, Siqing Zuo, Minghui Shi, Jiaqi Fan, Jingyu Xie, Guihua Xiao, Li Yu, Jiamin Wu, Qionghai Dai, Long-term intravital subcellular imaging with confocal scanning light-field microscopy. Nature Biotechnology, 2024.

Patents Granted:

[1] Dai Qionghai, Wu Jiamin, Xiao Guihua, Xie Hao, Zhang Yuanlong, CAI Yeyi, an optical computer interface technology for whole-brain multimodal neural activity detection, Patent of Invention, CN113712575B, 2023-5.

[2] XIAO Guihua, CAI Xinxia, Song Yilin, Xu Shengwei, Zhang Yu, LI Xinrong, Xie Jingyu, Dai Yuchuan, Wang Hao, LU Zeying; GABA and Electrophysiological micro-nano synchronous sensor detection chip and preparation method thereof, 2021-2-23, China, ZL201911219399.1