教育背景

2013-2019  清华大学 自动化系 工学博士

2009-2013  清华大学 自动化系 工学学士

工作履历

2022至今 清华大学信息国家研究中心 助理研究员

2019-2021 清华大学自动化系 博士后

学术兼职

曾担任Nature Communications、BMC Bioinformatics、Journal of Theoretical Biology等期刊的审稿人。

研究领域

单细胞生物信息学

合成生物学

研究概况

承担国家自然科学基金青年基金项目，参与国家重点研发计划、基金委原创探索计划项目等。以（共同）第一/通讯作者的身份在Cell Reports、Bioinformatics、Briefings in Bioinformatics等期刊发表多篇学术论文。

谷歌学术：https://scholar.google.com/citations?user=F1jKMakAAAAJ

学术成果

[1] Wei Zhang, Hanwen Xu, Rong Qiao, Bixi Zhong, Xianglin Zhang, Jin Gu, Xuegong Zhang, Lei Wei#, Xiaowo Wang#, ARIC: accurate and robust inference of cell type proportions from bulk gene expression or DNA methylation data. Briefings in Bioinformatics, 23 (2022) bbab362.

[2] Lei Wei*, Shuailin Li*, Pengcheng Zhang, Tao Hu, Michael Q. Zhang, Zhen Xie, Xiaowo Wang, Characterizing microRNA-mediated modulation of gene expression noise and its effect on synthetic gene circuits. Cell Reports, 36 (2021) 109573.

[3] Tao Hu*, Lei Wei*, Shuailin Li, Tianrun Cheng, Xuegong Zhang, Xiaowo Wang, Single-cell transcriptomes reveal characteristics of micrornas in gene expression noise reduction. Genomics, Proteomics & Bioinformatics, 19 (2021) 394–407.

[4] Jiaqi Li*, Lei Wei*, Xianglin Zhang, Wei Zhang, Haochen Wang, Bixi Zhong, Zhen Xie, Hairong Lv, Xiaowo Wang, DISMIR: Deep learning-based noninvasive cancer detection by integrating DNA sequence and methylation information of individual cell-free DNA reads. Briefings in Bioinformatics, (2021).

[5] Wei Zhang, Lei Wei#, Jiaqi Huang, Bixi Zhong, Jiaqi Li, Hanwen Xu, Shuying He, Yu Liu, Juhong Liu, Hairong Lv, Xiaowo Wang#, cfDNApipe: a comprehensive quality control and analysis pipeline for cell-free DNA high-throughput sequencing data. Bioinformatics, 37 (2021) 4251–4252.

[6] Xuehui Liu*, Lei Wei*, Qiongye Dong, Liyang Liu, Michael Q Zhang, Zhen Xie, Xiaowo Wang, A large-scale CRISPR screen and identification of essential genes in cellular senescence bypass. Aging (Albany NY), 11 (2019) 4011.

[7] Lei Wei*, Ye Yuan*, Tao Hu, Shuailin Li, Tianrun Cheng, Jinzhi Lei, Zhen Xie, Michael Q Zhang, Xiaowo Wang, Regulation by competition: a hidden layer of gene regulatory network. Quantitative Biology, 7 (2019) 110–121.

[8] 魏磊, 袁野, 汪小我, 合成基因线路规模化设计面临的挑战. 生物工程学报, 33 (2017) 372–385.

[9] Jiaqi Li, Zhenbin Qiu, Chao Zhang, Sijie Chen, Mengmin Wang, Qiuchen Meng, Haiming Lu, Lei Wei, Hairong Lv, Wenzhao Zhong, Xuegong Zhang, ITHscore: comprehensive quantification of intra-tumor heterogeneity in NSCLC by multi-scale radiomic features. European Radiology, 33 (2023) 893–903.

[10] Jiaqi Li, Zhuofeng Li, Lei Wei, Xuegong Zhang, Machine Learning in Lung Cancer Radiomics. Machine Intelligence Research, (2023) 1–30.

[11] Zheng Wei, Kui Hua, Lei Wei, Shining Ma, Rui Jiang, Xuegong Zhang, Yanda Li, Wing H Wong, Xiaowo Wang, NeuronMotif: Deciphering cis-regulatory codes by layer-wise demixing of deep neural networks. Proceedings of the National Academy of Sciences, 120 (2023) e2216698120.

[12] Xianglin Zhang, Xiaodong Jia, Bixi Zhong, Lei Wei, Jiaqi Li, Wei Zhang, Huan Fang, Yanda Li, Yinying Lu, Xiaowo Wang, Evaluating methylation of human ribosomal DNA at each CpG site reveals its utility for cancer detection using cell-free DNA. Briefings in Bioinformatics, 23 (2022) bbac278.

[13] Sijie Chen, Yanting Luo, Haoxiang Gao, Fanhong Li, Yixin Chen, Jiaqi Li, Renke You, Minsheng Hao, Haiyang Bian, Xi Xi, Wenrui Li, Weiyu Li, Mingli Ye, Qiuchen Meng, Ziheng Zou, Chen Li, Haochen Li, Yangyuan Zhang, Yanfei Cui, Lei Wei, Fufeng Chen, Xiaowo Wang, Hairong Lv, Kui Hua, Rui Jiang, Xuegong Zhang, hECA: The cell-centric assembly of a cell atlas. iScience, 25 (2022) 104318.

[14] Xiaofei Zhang, Tingting Cong, Lei Wei, Bixi Zhong, Xiaowo Wang, Jin Sun, Shuxia Wang, Meng Michelle Xu, Ping Zhu, Hong Jiang, Jianwei Wang, YTHDF3 modulates hematopoietic stem cells by recognizing RNA m6A modification on Ccnd1. Haematologica, 107 (2022) 2381.

[15] Xianglin Zhang, Xuehui Liu, Zhenhai Du, Lei Wei, Huan Fang, Qiongye Dong, Jing Niu, Yanda Li, Juntao Gao, Michael Q Zhang, Wei Xie, Xiaowo Wang, The loss of heterochromatin is associated with multiscale three-dimensional genome reorganization and aberrant transcription during cellular senescence. Genome Research, 31 (2021) 1121–1135.

[16] Tao Hu, Shixiong Xu, Lei Wei, Xuegong Zhang, Xiaowo Wang, CellTracker: an automated toolbox for single-cell segmentation and tracking of time-lapse microscopy images. Bioinformatics, 37 (2021) 285–287.

[17] Ye Wang, Haochen Wang, Lei Wei, Shuailin Li, Liyang Liu, Xiaowo Wang, Synthetic promoter design in Escherichia coli based on a deep generative network. Nucleic acids research, 48 (2020) 6403–6412.

[18] Zhen Zhao, Qiongye Dong, Xuehui Liu, Lei Wei, Liyang Liu, Yanda Li, Xiaowo Wang, Dynamic transcriptome profiling in DNA damage-induced cellular senescence and transient cell-cycle arrest. Genomics, 112 (2020) 1309–1317.

[19] Qiongye Dong, Lei Wei, Michael Q Zhang, Xiaowo Wang, Regulatory RNA binding proteins contribute to the transcriptome-wide splicing alterations in human cellular senescence. Aging (Albany NY), 10 (2018) 1489.

[20] Yuanyuan Li, Hui Zheng, Qiujun Wang, Chen Zhou, Lei Wei, Xuehui Liu, Wenhao Zhang, Yu Zhang, Zhenhai Du, Xiaowo Wang, Wei Xie, Genome-wide analyses reveal a role of Polycomb in promoting hypomethylation of DNA methylation valleys. Genome biology, 19 (2018) 1–16.

[21] 方欢, 钟碧溪, 魏磊, 张祥林, 张威, 汪小我, 血浆游离 DNA 全基因组甲基化测序的实用稳定性评估. 生物工程学报, (2019) 8.

[22] 胡冠华, 王也, 魏磊, 汪小我, 通过合成基因线路实现细胞分类. 生命科学, 30 (2018) 799–809.

[23] Qiongye Dong, Hongqing Han, Xuehui Liu, Lei Wei, Wei Zhang, Zhen Zhao, Michael Q Zhang, Xiaowo Wang, HCSGD: an integrated database of human cellular senescence genes. Journal of Genetics and Genomics, 44 (2017) 227–234.